NFL
Bills vs. Lions Odds, Predictions and Tips
Dec. 16 brings a thrilling Bills vs. Lions matchup that could set the stage for a Super Bowl LIX preview. Detroit enters as 2-point favorites with a strong defense and a dynamic offense. Buffalo’s offense, led by Josh Allen and Stefon Diggs, can turn any game into a highlight reel. Expect drama, tough matchups, and big plays.
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Stefon Diggs and Amon-Ra St. Brown//Getty Images
The Lions have been a legit force since their NFC Championship run. The Bills, though? They’re laser-focused on ending that Super Bowl drought since ’93. These teams don’t meet often, but when they do, it’s pure stuff. Just look at their last clash in Week 12 of 2022 — Buffalo edged Detroit 28-25 with a clutch 45-yard field goal from Tyler Bass... two seconds to spare.
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Bills vs. Lions Match Details
Kickoff Time: 2:55 A.M. ET
Location: Ford Field, Detroit, Michigan
Last meeting: Lions 25-28 Bills (Nov. 24, 2022)
Odds and Betting Tips: Bills vs. Lions
Get ready for a nail-biter! It’s Josh Allen’s grit versus the Lions’ roaring home dominance. With playoff stakes sky-high, this Week 15 clash promises fireworks. Here's the lowdown on odds and bets worth considering.
Pre-Game Odds and Betting Analysis
Pre-game Odds and Win Probability: Lions Slight Favorites
Bills: +110 – 43%
Lions: -130 – 57%
Odds courtesy of Betway, subject to change.
The Lions (11-1) roar into Week 15 as slight favorites, flexing a 57% win probability and -130 odds (courtesy of Betway). The Bills (10-3), rocking a +110 underdog tag and a 43% shot, aren’t here to play second fiddle.
Buffalo’s got the maestro of magic moments, Josh Allen — but he’ll face a fired-up Lions defense that’s been locking it down at home all season. Meanwhile, Detroit’s offense is all gas, no brakes, testing Buffalo’s shaky D in what could be a barnburner.
With playoff hopes on the line, it’s Allen vs. momentum. Let’s see if the Bills shock the Motor City, or the Lions keep their NFC crown polished.
Bills vs Lions Against the Spread (ATS):
- Bills +2 (-110)
- Lions -2 (-110)
The Lions step into this showdown as 2-point favorites, but don’t sleep on the Bills (+2, -110). Buffalo’s knack for delivering under pressure makes them an enticing bet to cover the spread.
QB Allen’s offense can keep pace in any game, and the Bills have consistently kept it close, even against top-tier squads. But Detroit’s defense at Ford Field (arguably their secret weapon) could tip the scales.
This matchup feels razor-thin, with the Lions’ home dominance clashing against Buffalo’s big-play ability. Betting on either side comes with its thrills.
Bills vs Lions Over/Under (O/U): 50.5
- Over (-115)
- Under (-105)
The Over/Under for Bills vs. Lions is set at 50.5 points, with Over (-115) slightly favored over Under (-105).
Why lean toward the Over? You see, both teams are lighting up scoreboards this season. Detroit averages an excellent 31.9 points per game, while Buffalo ain’t far behind at 29.6. With Allen and Goff playing at an elite level, this has all the makings of a shootout.
Still, don’t overlook the Buffs’ defense, ranked 11th, which could disrupt Detroit’s rhythm. If the Lions' offense stumbles, the Under might sneak into play. But with these teams’ offensive firepower, the Over feels like the safer bet.
Suggested Bets
Over 50.5 Points: Both teams are offensive powerhouses, averaging a combined 61.5 points per game. This matchup has all the makings of a high-scoring shootout. (Over -115 with Betway)
Bills to Cover the Spread (+2): Buffalo thrives in tight games and underdog spots. Even against Detroit’s stout home defense, expect the Bills to keep this close. (-110 with Betway)
Lions Moneyline (-130): The Lions’ 11-1 record and dominance at Ford Field make them a strong pick to secure the win, especially with a 57% implied probability. (-130 with Betway)
Bills vs. Lions Head-To-Head Record
Out of 12 regular-season matchups, the Bills have the edge with a 7-4-1 record. These games are tight — Buffalo’s only outscoring Detroit by five points, 226-231.
Right, and their last clash in 2022? A nail-biting 28-25 win for the Bills, but it was far from a walk in the park.
Detroit’s been bringing the heat, making this rivalry way spicier than anyone expected. Both teams are firing on all cylinders right now, so you know this one's going to be full of fireworks, drama, and some hard hits.
Last Five Meetings
24/11/22: Bills 28-25 Lions
16/12/18: Lions 13-14 Bills
05/10/14: Bills 17-14 Lions
14/11/10: Lions 12-14 Bills
15/10/06: Bills 17-20 Lions
The Buffalo Bills: Current Form
The 10-2 Bills are charging full steam toward playoff glory. With 249 total first downs (versus opponents’ 231), this offense has been a chain-moving machine. Be it pounding it on the ground (100 rushing first downs) or flying high through the air (124 passing), Buffalo’s balance has been their biggest weapon.
Josh Allen continues to cook, slinging 2,700 passing yards on 233 completions (averaging 7.5 yards per toss). But don’t sleep on their run game — it’s churned out 1,531 yards at a steady 4.4 per carry.
Defensively, the Buffs boast a +17 turnover ratio. Their offense has lit up the scoreboard with 43 TDs (21 rushing, 20 passing). And Tyler Bass? The man’s clutch, nailing 19 of 23 field goals to keep the points flowing.
Key Players to Watch
- Josh Allen: Allen’s a one-man highlight reel. The Bills’ fearless leader is built like a freight train with the finesse of a ballerina, capable of torching defenses through the air or bulldozing them on the ground. Allen’s playmaking magic keeps Buffalo in every game, making him the ultimate wild card on-field.
- WR Keon Coleman: Coleman steps into Buffalo’s lineup with serious potential and a chance to shine in their revamped "everyone eats" offense. As part of Allen’s arsenal, the rookie wideout brings explosive playmaking to a system designed for spreading the love — and the yardage.
- Connor McGovern: He’s stepping up to anchor Buffalo’s O-line as their new center, bringing leadership and a steady hand to a pivotal role. After a solid stint at left guard, he’s ready to snap, lead, and set the tone for Allen’s protection.
Remaining Bills Schedule
- Week 14: vs. Los Angeles Rams (Monday, Dec. 9; 2:55 A.M)
- Week 15: vs. Detroit Lions (Monday, Dec. 16; 2:55 A.M)
- Week 16: vs. New England Patriots (Dec. 22; 11:30 PM)
- Week 17: vs. New York Jets (Dec. 29; 11:30 PM)
- Week 18: at New England Patriots (Jan 5; TBD)
The Detroit Lions: Current Form
The Lions are officially playing like they’ve got something to lose. With 279 total first downs, including a striking 108 on-ground, they’re charging down the field like they own it. QB Goff’s got 2,982 passing yards and a slick 8.8 yards per attempt.
Don’t sleep on the Lions’ rushing game — 1,853 yards at 4.8 per carry is no joke.
On the defensive side? They’re showing out too — 24 sacks and a +8 turnover ratio. Throw in their efficient 21-of-24 field goal conversion rate, and the Lions are proving they can do it all.
Key Players to Watch
- Penei Sewell: Sewell isn’t just Detroit’s top tackle — he’s their O-line superhero. With a knack for mowing down defenders and creating space in both pass protection and the run game, he’s a nightmare matchup. Plus, his downfield blocking? Almost unfair, man! He’s like the literal foundation of Detroit’s gritty front.
- QB Jared Goff: Goff’s transformation mirrors the Lions' rise. From doubted to dominant, he’s become the cool-headed leader Detroit never knew it desperately needed. His smooth synergy with Ben Johnson’s offense and calm under pressure make him the guy for crunch-time plays and NFC takeovers.
- WR Amon-Ra St. Brown: Brown plays with a “prove-you-wrong” energy that’s as relentless as his route running. From draft-day chip to All-Pro dominance, he’s all about the grind.
Lions’ Remaining Schedule
- Week 15: vs. Buffalo Bills (Monday, Dec. 16; 2:55 A.M)
- Week 16: vs. Chicago Bears (Dec. 22; 11:30 PM)
- Week 17: vs. San Francisco 49ers (Dec. 31; 6:45 AM)
- Week 18: vs. Minnesota Vikings (Jan 5; TBD)
Predicted Line-Ups
Buffalo Bills:
Offense:
QB: Josh Allen
RB: James Cook
WR: Amari Cooper
TE: Dalton Kincaid
FB: Reggie Gilliam
OL: Dion Dawkins (LT), David Edwards (LG), Connor McGovern (C), O'Cyrus Torrence (RG), Spencer Brown (RT)
Defense:
LDE: Greg Rousseau
LDT: DaQuan Jones
RDT: Ed Oliver
RDE: AJ Epenesa
WLB: Matt Milano
MLB: Terrel Bernard
SLB: Nicholas Morrow
LCB: Rasul Douglas
SS: Taylor Rapp
FS: Damar Hamlin
RCB: Christian Benford
NB: Taron Johnson
Special Teams:
PK: Tyler Bass
P: Sam Martin
H: Sam Martin
PR: Brandon Codrington
KR: Brandon Codrington
LS: Reid Ferguson
Detroit Lions:
Offense:
QB: Jared Goff
RB: David Montgomery
WR: Amon-Ra St. Brown
WR: Jameson Williams
WR: Tim Patrick
TE: Sam LaPorta
OL: Taylor Decker (LT), Graham Glasgow (LG), Frank Ragnow (C), Kevin Zeitler (RG), Penei Sewell (RT)
Defense:
LDE: Za'Darius Smith
LDT: Alim McNeill
RDT: DJ Reader
RDE: Josh Paschal
WLB: Trevor Nowaske
MLB: Jack Campbell
SLB: Ezekiel Turner
LCB: Carlton Davis III
SS: Brian Branch
FS: Kerby Joseph
RCB: Terrion Arnold
NB: Amik Robertson
Special Teams:
PK: Jake Bates
P: Jack Fox
H: Jack Fox
PR: Kalif Raymond
KR: Khalil Dorsey
LS: Craig Reynolds
Key Matchup: Bills Offense vs. Lions Defense
Here’s the kicker: it’s the high-flying Bills offense vs. the Lions defense’s sneaky pressure. Allen’s the maestro in Buffalo, with Stefon Diggs sprinting downfield like he’s got a jetpack.
But Detroit’s defense has been quietly wreaking havoc. If they can get in Allen’s face and mess with his flow, the Bills’ offense could hit a speed bump.
On the flip side, the Lions are running hot. Gibbs and Montgomery are bulldozing through defenses like it’s a demolition derby. The Bills’ defense? They’ve shown they can lock things down, but when it comes to stopping the run, they’ve been a little leaky. If Detroit’s ground game gets going, Buffalo’s defense could be in for a long day.
Bills vs. Lions Prediction
Alright, the Bills vs. Lions matchup’s a total nail-biter in the making. For bettors, those Bills at +2 (-110) are looking like some solid value. Sure, Detroit’s been the more consistent squad this season, but c’mon — Buffalo's playmakers can turn any game into a highlight reel. They’ve got that upset potential.
But again, Detroit’s got the upper hand right now. They’ve been steady, while the Bills? They’ve been all over the place — one minute explosive, the next, not so much. But it’ll be tight.
Prediction: Bills 24, Lions 26.
This game’s got options. But keep an eye on injury updates and line movements. Stuff can change fast in the NFL.
Heena Singh is your go-to NFL writer with a knack for turning the gridiron’s biggest moments into must-read stories. She brings a unique mix of sharp insights and quirky vibes, breaking down every touchdown, fumble, and post-game drama like a pro. A die-hard fan of the Kansas City Chiefs (and yes, Patrick Mahomes is her guy), Heena knows how to keep football fans hooked.
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