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Southampton vs Arsenal Preview: Odds, Tips, and Prediction

Date: 25 May 2025 Kick-off (UK Time): 16:00 Venue: St. Mary's Stadium Southampton are at home to Arsenal on the final day of the season in the Premier League on Sunday, 25 May 2025. The home side comes into the encounter at the bottom of the league while Arsenal is pushing for a second-placed finish. This matchup at St. Mary’s carries real weight for Premier League betting, with contrasting stakes at both ends of the table.

Nigel Naicker

Betting Writer

Last updated: 2025-05-20

Fact checked by:

Chad Nagel

Sports & Betting Editor

7 minutes read

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Joe Aribo with Declan Rice/ Getty Images

Table of Contents

The Saints have had a torrid time back in the Premier League and are set to go down with the second-lowest points tally (12) in the history of the competition. The Gunners’ season has been impressive, even though they have slowed down in the league and allowed Liverpool to run away with the league title, there are some positives to take with the Champions League semi-final run.
Tightly contested fixtures like this often come down to fine margins, making it useful to consider how various football betting strategies might influence your approach.

Pre-Game Odds and Win Probability

Home: 11/10 (2.10) – 20.8%
Draw: 5/2 (3.50) – 28.6%
Away: 13/5 (3.60) – 54.6%
Odds courtesy of Betway, subject to change.

Head-to-Head Record

05/10/24 – Arsenal 3-1 Southampton
21/04/23 – Arsenal 3-3 Southampton
23/10/22 – Southampton 1-1 Arsenal
16/04/22 – Southampton 1-0 Arsenal
11/12/21 – Arsenal 3-0 Southampton

Southampton Current Form - LDLLD

Cameron Archer(L) of Southampton celebrates with Kyle Walker-Peters(R) after opening the scoring.jpg

It has been a season to forget back in the Premier League for the Saints. They are winless in their previous five fixtures and only accumulated 12 points in the league all season.

Key Players to Watch

Mateus Fernandes
The Portuguese youngster looks like he is a real prospect. The 20-year-old has five goal contributions in 34 appearances in the league this season.
Kamaldeen Sulemana
The 23-year-old Ghanaian has become an important figure for the Saints. He has featured 24 times in the Premier League and can play on the wing and lead the line.
Kyle Walker-Peters
The former Tottenham Hotspur fullback has been a consistent performer for Southampton this campaign. He has featured in 33 games this season and has two assists to his name.

Southampton Team News

After struggling with many injuries during the season, the Saints have a clean bill of health going into the final couple of games. The only concern is over Walker-Peters, who had an illness, but the fullback should be back for the visit of Arsenal.

Arsenal Current Form – DWDLD

Bukayo Saka of Arsenal celebrates after scoring the third goal.jpg

Mikel Arteta’s side has struggled towards the end of the season domestically, and their previous five fixtures are testament to that. The Gunners have won just once, while drawing three times and losing the other game in that period.

Key Players to watch

Mikel Merino
The midfielder come striker has had an excellent debut season in North London. Merino’s versatility and football IQ make him one of the standout performers in Arteta’s side.
David Raya
The Spanish shot-stopper has been ever reliable between the sticks for Arsenal and has pulled off some vital stops this season for his side.
Bukayo Saka
Saka is the Gunners’ main man. Everything flows through him down the right wing, and the Englishman is a nightmare to deal with for opposition defenders.

Arsenal Team News

Gabriel has a hamstring strain. Takehiro Tomiyasu and Gabriel Jesus both suffered knee injuries and are the long-term absentees. Jorginho has a chest problem. In some good news for Arsenal, Kai Havertz has returned to full training and Declan Rice has shrugged off a minor muscle injury.

Predicted Line-Ups:

Southampton (4-2-3-1): Ramsdale, Manning, Bella-Kotchap, Stephens, Walker-Peters, Ugochukwu, Aribo, Wellington, Fernandes, Gronbaek, Onuachu
Arsenal (4-3-3): Raya, White, Saliba, Kiwior, Lewis-Skelly, Partey, Rice, Odegaard, Saka, Martinelli, Nwaneri.

Suggested Bets

There are plenty of trusted betting sites in our preview for you to place your wagers with.

Both Teams to Score (Yes) Both teams registered goals in three of the last five fixtures (17/20 with Betway)
Over 2.5 Goals: Three of the last five fixtures between these two sides saw over 2.5 goals. (14/25 with Betway).

Value Bets

Check out these value wagers for your football betting in the clash between Southampton and Crystal Palace.

Gabriel Martinelli Anytime Goal Scorer: The Brazilian has found form at the back end of the season and has been clinical in front of goal. (Forecast odds: 3/1)
First Half (Arsenal): Arsenal are generally fast starters, and the Saints have been leaking goals at home. (4/5 with Betway)

Prediction: Arsenal to Win

The home side will be desperate to be put on a show in front of the Saints’ fans, but Arsenal will eventually find a way through. Southampton has conceded the most goals in the division. Back the Gunners to run riot on Sunday.

Nigel NaickerBetting Writer

With a decade of sports writing expertise, Nigel Naicker has crafted compelling content across football leagues like the Premier League and UEFA Champions League, as well as cricket and UFC. A passionate storyteller since 2014, Nigel joins the SportsBoom team, ready to deliver insightful narratives across various sports disciplines.